Results of Surgical Treatment of Ocular Adnexa Tumors

Objective. To develop a methodology for the surgical treatment of malignant tumors of the ocular adnexa (MTOAs).
Material and methods. To improve surgical outcomes in patients with MTOAs, we developed methods for personalized radical surgical treatment of locally advanced and recurrent MTOAs. Surgical treatment was assessed based on the nature and frequency of postoperative complications. Long-term evaluation of treatment effectiveness was based on an analysis of 5-year recurrence-free survival (RFS) and 5-year overall survival.
Results. The study included 580 patients who underwent surgical treatment at the Clinic of the Bashkir State Medical University between 2008 and 2023. Radical resection of stage T1-T2 MTOAs presents no difficulties, but adherence to standard recommendations for the distance from the tumor margin to the resection margin requires a reconstructive stage of the surgery, which limits the capabilities of surgeons who are not skilled in plastic closure techniques. The developed personalized methodology for radical surgical treatment of MTOAs significantly reduces the recurrence rate and 5-year RFS in patients at stages T3-Tx with preserved visual acuity.
Conclusion. The developed methodology for radical surgical treatment of locally advanced and recurrent MTOAs, using a personalized approach to determining the distance from the visible tumor margin to the resection margin, taking into account the risk of recurrence and infiltration of bone structures, the outer layers of the eye, and extraocular muscles, results in a 5-year survival rate of 91.4% and a significantly higher RFS in 89.5% of cases.
Keywords: adnexa, malignant tumor, radical treatment, personalized methodology for radical surgical treatment, visual acuity, postoperative defect, locally advanced process, cancer recurrence
Conflict of interest. The authors declare no conflict of interest.
Funding. The study was performed without external funding. Authors are responsible for ensuring compliance with national and local regulations when conducting research involving human participants.