Experience of 15-year clinical application of antimicrobic photodynamic therapy for purulent maxillary sinusitis treatment

Background. The problem of purulent maxillary sinusitis (PMS) treatment remains relevant, despite the widespread use of modern antibacterial agents and antifungal drugs, introduction of modern methods of surgery, including minimally invasive endoscopic laser, ultrasound and others.

Aim. To increase the efficiency of acute (catarrhal, purulent) and chronic (catarrhal, purulent, fungal) maxillary sinusitis treatment with the use of photodynamic therapy.

Materials and methods.

Within the last 15 years 320 patients with acute and chronic PMS underwent a minimally invasive treatment with APDT. The method described in the article was initially applied only in cases when the previous treatment, including surgical treatment, did not provide a stable effect, or in those cases when the patient had an allergic reaction to one of antibacterial drugs. The sessions of APDT were conducted both in hospital and in outpatient settings. Only Russian photosensitizer Radakhlorin, the domestic laser medical device “Lakhta-Milon” and domestic quartz-polymer fibers were used to produce laser irradiation of the maxillary sinus cavity. The APDT technique development and obtaining positive results allowed using it as the main method for primary PMS treatment.

Results. The long-term results of APDT use showed its effectiveness for the treatment of PMS, but it also has contraindications, namely: odontogenic PMS; polypous PMS and individual intolerance to Radachlorin and light. The use of APDT allowed to achieve a complete response, confirmed by clinical and microbiological data in 288 (90%) of 320 patients with PMS. Key words: photodynamic therapy, maxillary sinusitis, radachlorin.

Authors declare no conflict of interests for this article. Source of financing. Unspecified.

For citations: Isaev V.M., Nasedkin A.N., Egorov V.I., Zalevskaya O.I., Isaev E.V., Pustovit O.M., Fetisov I.S. Experience of 15-year clinical application of antimicrobic photodynamic therapy for purulent maxillary sinusitis treatment. Golova I Sheya. Head and neck. Russian Journal. 2018;6(2):55–61 (in Russian).

 The authors are responsible for the originality of the presented data and the possibility of publishing illustrative material – tables, drawings, photographs of patients.