Zarichanskij V.A., Chkadua T.Z., Egiazaryan A.K., Sogachev G.V. Modern concept of generalized neurofibromatosis type I: diagnosis, treatment. Head and neck. Russian Journal. 2023;11(1):28–36 The authors are responsible for the originality of the data presented and the possibility of publishing illustrative material – tables, drawings, photographs of patients.


The article is devoted to the most common hereditary disease predisposing to the occurrence of tumors in humans – neurofibromatosis type 1, belonging to the group of phacomatosis. Patient observations were carried out at the hospital bases of three centers in the departments of maxillofacial surgery and neurosurgery. Neurofibromatosis is a group of systemic hereditary diseases characterized by developmental defects of ecto-mesodermal structures, mainly of the skin, nervous and bone systems. The disease has many concomitant factors that often make diagnosis more difficult.

Key words: neurofibromatosis, neurofibroma, neurofibromatosis type I, Recklinghausen’s disease, nervous system, сutaneous neurofibroma, Lisch nodules, NF-1 gene, inherited diseases
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study

Download PDF