Liposomal-antioxidant complex in the prevention and treatment of reperfusion syndrome. Experimental study

Despite the improvement of blood circulation restoration methods in acute ischemia of various localizations and the use of anticoagulant and antiplatelet therapy to maintain the reperfused artery patency, there is still no effective
prevention of reperfusion tissue injury, which determined the aim and objectives of the present study.
Objective of the study. The article presents our own data on the effect of intravenously injected liposomal antioxidant complex «Flamena» on the degree of myocardial damage in rats in the ischemia-reperfusion model.
Material and Methods. The study was performed on 53 mature male white outbred rats.
Results. The efficacy of the agent has been shown, expressed by a decrease in the size of irreversibly damaged
tissues, a decrease in the percentage of large infarctions. The optimal dose of the substance in experimental myocardial infarction was found to be 2.9 ml/kg.
Conclusion. The efficacy of liposomal-antioxidant complex «Flamena», especially demonstrated on the traumatic experimental IR model in small laboratory animals with prolonged ischemia, suggests the potential of this method
of reperfusion injury prevention in acute ischemic events and dictates the need for further research.
Keywords: liposomal-antioxidant complex «Flamena», prevention and treatment of reperfusion syndrome, myocardium
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study
For citation: Matveev D.V., Gavrilova S.A., Kuznetsov M.R., Akhmetshina M.R., Ivanov E.V., Evteev A.V.,
Kuznetsova M.M., Nochnoy M.S. Liposomal-antioxidant complex in the prevention and treatment of reperfusion syndrome. Experimental study. Head and neck. Russian Journal. 2022;10(4):16–23