Kastyro I.V., Reshetov I.V., Popadyuk V.I., Torshin V.I., Ermakova N.V., Karpukhina O.V., Inozemtsev A.N., Khamidulin G.V., Shmaevsky P.E., Sardarov G.G., Gordeev D.V., Scopich A.A. Studying the physiological effects of a new model of septoplasty in rats. Head and neck. Russian Journal. 2020;8(2):33–38 (in Russian).
DOI: https://doi.org/10.25792/HN.2020.8.2.33-38
Physiological responses to the proposed rat septoplasty model under general anesthesia were investigated. We studied the motor activity of rats and heart rate variability before experiment, one day and two days after surgery. After surgical intervention, motor activity decreased, the time of fading and grooming increased, the value of HF decreased, and VLF increased. Surgical trauma of the nasal septum mucous membrane in rats in the early postoperative stage contributes to a powerful stress response in the form of a shift in the balance of the autonomic nervous system towards the sympathetic nervous system, causes mobilization of central regulation mechanisms, reduces research activity, and provokes an anxious, depressive-like state and anxiety in rats.
Key words: septoplasty, stress, motor activity, grooming, heart rate variability, VLF, LF, HF, centralization index
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study.
For citation: Kastyro I.V., Reshetov I.V., Popadyuk V.I., Torshin V.I., Ermakova N.V., Karpukhina O.V., Inozemtsev A.N., Khamidulin G.V., Shmaevsky P.E., Sardarov G.G., Gordeev D.V., Scopich A.A. Studying the physiological effects of a new model of septoplasty in rats. Head and neck. Russian Journal. 2020;8(2):33–38 (in Russian).
The authors are responsible for the originality of the data presented and the possibility of publishing illustrative material – tables, figures, photographs of patients.