Evaluation of guided bone regeneration outcomes on the background of hypoxen treatment in chronic periodontitis

Periodontitis is one of the most common oral diseases caused by bacterial plaque microorganisms and influenced by factors such as the systemic condition of the human body, oral hygiene, age, gender, and smoking status. Excessive free radical concentrations caused by oxidative stress or antioxidant deficiency are associated with periodontal disease. Guided bone regeneration is a common method of modeling the alveolar process with different modifications depending on the choice of bone material and membrane. The reason for unsatisfactory treatment outcomes is a decrease in the physiological antioxidant system activity, which leads to the development of periodontal hypoxia and further to the destruction of collagen fibers and bone tissue. Hypoxia slows down all regenerative processes, including surgically initiated processes such as guided bone regeneration. Thus, without normalization of the oxidative background, treatment will not yield the expected results.

Keywords: periodontitis, oxidative stress, guided bone regeneration, hypoxene, antioxidant, antihypoxic

Conflicts of interest. The authors have no conflicts of interest to declare.

Funding. There was no funding for this study