Yakovlev S.V., Topolnitsky O.Z., Lezhnev D.A., Zhuravleva A.V., Gurgenadze A.P., Fedotov R.N. Diagnostics and treatment of intraosseous myofibromas in childhood (clinical observations). Head and neck. Russian Journal. 2023;11(1):54–61
The authors are responsible for the originality of the data presented and the possibility of publishing illustrative material – tables, drawings, photographs of patients.
Presented here are two cases, rare in children, of myofibroma involving the mandible in a 3-year-old and 15-year- old patients. The diagnosis was established only after biopsy and histopathological examination, and long-term follow-up did not reveal a relapse.
Myofibroma is a rare benign neoplasm of fusiform cells that occurs predominantly in young children. Classically these lesions are described in children younger than two years old and rarely in adults. Most of lesions are localized in the lip, buccal mucosa, and tongue. For them to occure in the jaws is very rare. These lesions are a benign fibroblast and myofibroblast proliferation containing a biphasic presentation of spindle-shaped cells surrounding a central zone of less differentiated cells focally arranged in a hemangiopericytoma like pattern. The rarity of this disease makes it difficult to diagnose for clinicians, radiation diagnosticians and histopathologists. Myofibroma has an aggressive clinical presentation and is often treated aggressively because of an inappropriate diagnosis.
Key words: mandible, myofibroma, spindle cell neoplasm
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study