Golanov A.V., Bekyashev A.H., Tushev A.A., Banov S.M., Moldovanov V.A., Dreeva A.R. Combined treatment of newly diagnosed diffuse astrocytomas with a low index of proliferative activity. Head and neck. Russian Journal. 2020;8(3):25–34 (in Russian).
The authors are responsible for the originality of the data presented and the possibility of publishing illustrative material – tables, figures, photographs of patients.
Objective. To study the indicators of overall (OS) and disease-free survival in patients with newly diagnosed diffuse astrocytomas (WHO Grade II) with a low index of proliferative activity after combination treatment. To assess the influence of various factors on survival rates.
Material and methods. The analysis of the treatment results of 153 patients (73 men and 80 women) with newly diagnosed diffuse astrocytomas (WHO Grade II) with a low index of proliferative activity (less than 5%) was carried out. The mean time of clinical follow-up was 4.8±2.71 years.
Results. The univariate analysis revealed that disease-free survival was influenced by: tumor extent (p=0.01) and postoperative radiation therapy (p=0.0747). OS was influenced by the presence of neurological deficit before surgical treatment (p=0.0092), tumor extent (p=0.0799) and the volume of surgical resection (p=0.0377). During the multivariate analysis, statistically significant factors in the prognosis of OS were headache (p=0.0338), tumor size (p=0.0102) and resection completeness (p=0.0164). As for disease-free survival, statistically significant were headache (p=0.0119), tumor size (p=0.0001), postoperative complications (p=0.0196), and postoperative radiation therapy (p=0.0496 ).
Conclusions. Significant prognostic factors are tumor size before surgical treatment and completeness of surgical treatment; radiation therapy improves disease-free survival without affecting OS.
Key words: diffuse astrocytomas, low index of proliferative activity, survival rates, combined treatment
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study.