Prokhorova A.I., Samoilova S.I., Levendyuk O.A., Didenko M.I., Ryzhova M.V., Reshetov I.V., Svyatoslavov D.S., Efremov G.D., Sukorceva N.S., Sinelnikov M.E. A clinical case of sinonasal SMARCB1- deficient carcinoma. Head and neck. Russian Journal. 2022;10(4):62–677


Synonasal carcinomas with SMARCB1 deficiency represent a new group of rare malignant neoplasms recently described in the literature. Given the aggressive na-ture of these tumors, timely diagnosis is especially important. In this article, based on the example of a clinical case, the key pathomorphological features of this tu-mor will be considered, followed by differential diagnosis.
Key words: synonasal undifferentiated carcinoma (SNUC), synonasal SMARCB1-deficient carcinoma, SWI / SNF protein complex, SMARCB1 gene, synonasal neuroendocrine carcinoma
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study

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