Khlystalov M.V., Moroz S.E., Kastyro I.V., Lavrentieva E.A., Ibadullaeva S.S., Ganshin I.B., Shalamov K.P., Popadyuk V.I., Drozdova G.A., Kostyaeva M.G., Kartasheva A.F., Barannik M.I., Sarygin P.V. Angiogenesis in the autologous adipose tissue graft after various methods of preoperative fat treatment in rats. Head and neck. Russian Journal. 2024;12(3):57–62
DOI: https://doi.org/10.25792/HN.2024.12.3.57-62
The article presents studies of angiogenesis in the autologous adipose tissue graft after various methods of its preoperative processing (solid graft, fragmenting with a scalpel, fat homogenized using a Luer Lock syringe) in rats at 30, 90 and 180 days after lipofilling simulation. We found that the number of microcirculatory vessels (MCVs) in the recipient site after 30 days was significantly lower in the fragmented fat group (p<0.05) compared with the solid graft group (p<0.05). After 90 days, the lowest proportion of MCVs was in the homogenized fat group (p<0.01). At 180 days after simulated lipofilling, the highest number of MCVs was observed in the homogenized fat group compared with the fragmented fat group (p<0.001). In all groups, the proportion of MCVs decreased significantly from day 30 to day 180. The best vascularization of adipose tissue at 180 days after lipofilling simulation in rats was observed with the transplantation of homogenized fat. Key words: lipofilling, fat graft, neoangiogenesis, microvasculature Conflicts of interest. The authors have no conflicts of interest to declare. Funding. There was no funding for this study